Structural Studies of the Mycotoxin Verrucosidin

Document Type

Article

Publication Date

1-1-1984

Abstract

Structure 1 has been established for verrucosidin, a neurotoxin isolated from Penicillium verrucosum var. cyclopium. A novel fragmentation in base yields aldehyde 3 and a rearranged cyclopentenone carboxylic acid. The structure of the methyl ester 4 of this acid has been established by independent synthesis. A mechanism is proposed for the formation of the cyclopentenone ring of 4 from the epoxy ?-pyrone of 1. © 1984, American Chemical Society. All rights reserved.

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