Antimicrobial activity of some thiourea derivatives and their nickel and copper complexes
Document Type
Article
Publication Date
1-1-2009
Abstract
Five thiourea derivative ligands and their Ni2+ and Cu 2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed. © 2009 by the authors; licensee Molecular Diversity Preservation International.
Recommended Citation
Arslan, Hakan; Duran, Nizami; Borekci, Gulay; Ozer, Cemal Koray; and Akbay, Cevdet, "Antimicrobial activity of some thiourea derivatives and their nickel and copper complexes" (2009). College of Health, Science, and Technology. 27.
https://digitalcommons.uncfsu.edu/college_health_science_technology/27