Preparation of 3?azetidinols with non?bulky 1?alkyl substituents
Abstract
Cyclization of either the tetrahydropyranyl or trimethylsilyl ether of 1?(alkylamino)?3?chloro?2?propanols 1 followed by cleavage of the azetidinyl ether provides a general method for the preparation of 1?alkyl?3?azetidinols. Unhindered amines provide a more facile preparation of derivatives of 1, or its ethers, than do hindered amines, while hindered derivatives of 1 undergo more facile ring closure. Copyright © 1987 Journal of Heterocyclic Chemistry
This paper has been withdrawn.